APPLICATIONS OF TECHNOLOGY:
- Actinide contamination therapies
- Cancer research
- Strong, selective binding to Th(IV)
- Fast kinetics
- Water soluble
Berkeley Lab researcher Kenneth N. Raymond and colleagues have developed a Thorium (IV) (Th(IV)) sequestering agent that can be used to bind Th(IV) in water very rapidly at extremely low concentrations. The new agent is a macrocyclic octadentate ligand, 2,3,-Dihydrooxyterephthalamide, called ThL, for short, when bound to Th(IV). Inspired by siderophores, naturally occurring iron-chelating compounds produced by bacteria, the macrocyclic molecule is able to have fast kinetics and extraordinarily strong binding to Th(IV), yet is water soluble.
The Berkeley Lab technology can be modified to develop highly specific chelators of lanthanides or other actinides such as plutonium, uranium, or neptunium. The molecules can be tailored to find and sequester radioactive particles, making them soluble for flushing out of the body. Therefore they could be developed into oral chelating agents for radioactive decontamination.
The reverse of this propensity to seek out and bind to actinides makes these sequestering agents, and ThL in particular, attractive for cancer diagnostics or radiotherapy. (Th(IV) isotope 227 has a relatively short half-life and emits α-radiation, which is highly desirable as a tumor killer due to both its high energy and range of about one human cell width.) If paired with tumor-specific antibodies, ThL could transport lethal doses of Th(IV) radiation directly to cancer cells, simultaneously flagging tumor sites while killing tumor cells. The molecule could also be used to sequester zirconium-89, a short half-life isotope that is widely used as a tracer for positron emission tomography (PET) scans.
DEVELOPMENT STAGE: Bench scale prototype
STATUS: Patent pending. Available for licensing or collaborative research.
SEE THESE OTHER BERKELEY LAB TECHNOLOGIES IN THIS FIELD:
REFERENCE NUMBER: IB-3232