Lawrence Berkeley National Laboratory masthead A-Z Index Berkeley Lab masthead U.S. Department of Energy logo Phone Book Jobs Search
Tech Transfer
Licensing Interest Form Receive Customized Tech Alerts

Mobile Ex Situ High Resolution NMR and MRI

IB-1717

The Berkeley Lab ex situ NMR and MRI technique can be used for oil well logging (left), stand-off detection (top right), and cargo inspection (bottom right).

APPLICATIONS:

  • Industrial sensing
  • Oil well logging
  • Medical imaging for large subjects
  • Spectroscopy
  • Imaging subjects or objects with ferromagnetic components
  • Cargo inspection
  • Stand-off detection

ADVANTAGES:

  • Samples can be outside of magnet
  • Generates high resolution spectra
  • Quick and transportable
 
NMR spectrum of trans-2-pentenal under ordinary high resolution conditions. Peaks corresponding to the five non-equivalent hydrogen nuclei are observed.
Spectrum with sample placed in a non-uniform field outside of the rf coil; all chemical information is lost.
A specially designed rf pulse train (inset rectangles) nuclei in a non-uniform magnetic field; a high resolution spectrum is recovered from the emitted signal.

ABSTRACT: Alexander Pines and colleagues have opened the way to high resolution ex situ nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). NMR/MRI experiments are typically performed with samples immersed in a magnet shimmed to high homogeneity. However, in many circumstances it is impractical or undesirable to transport or insert samples into the bore of a high field magnet.

The Berkeley Lab researchers have developed an NMR/MRI technique in which a mobile magnet can be scanned over a stationary sample. The resulting high resolution spectra have full chemical shift information despite the inhomogeneous static and radio frequency fields normally associated with ex situ NMR/MRI.

Preliminary experiments using Berkeley Lab’s ex situ NMR method show that line broadening due to static field gradients of up to 0.5 mT/cm can be effectively overcome. Berkeley Lab’s technique has been applied to multidimensional spectroscopy and can be extended to spin decoupling and multiple-pulse sequences, and Magic-Angle Spinning (MAS) for static samples located outside the magnet.

 

STATUS: U.S. Patent #6,674,282. Available for licensing

REFERENCE NUMBER: IB-1717

PUBLICATION:

Meriles, C., Sakalleriou, D., Heise, H., Moule, A., Pines, A., “Approach to High Resolution Ex Situ NMR Spectroscopy,” Science 2001, 293, 82-85.

SEE THESE OTHER BERKELEY TECHNOLOGIES IN THIS FIELD:

See More Imaging Technologies
Last updated: 09/17/2009