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Genes Encoding Telomere-Associated Proteins

IB-1317
 

Ernest Orlando Lawrence Berkeley National Laboratory

 

a, Metaphase chromosomes from uninfected cell stained with anti-TIN2 (endogenous TIN2) antibody. b, Metaphase chromosomes from Myc–TIN2-expressing cell stained with anti-Myc (retroviral TIN2) antibody. c, Interphase nucleus of an HA–TRF-1/Myc–TIN2-expressing cell stained with anti-Myc (retroviral TIN2) antibody. d, Interphase nucleus of the same HA–TRF-1/Myc–TIN2-expressing cell stained with anti-HA (retroviral TRF1) antibody. e, Co-localization of HA–TRF1 and Myc–TIN2 in nucleus shown in (c) and (d) (merged image). f, DAPI staining of nucleus shown in (c–e). g, Interphase nucleus of another HA–TRF-1/Myc–TIN2-expressing cell stained with anti-Myc (retroviral TIN2) antibody. h, Interphase nucleus of the same HA–TRF-1/Myc–TIN2-expressing cells stained with anti-HA (retroviral TRF1) antibody. i, Co-localization of HA–TRF1/Myc–TIN2 in nucleus shown in (g) and (h) (merged image). j, DAPI staining of nucleus shown in (g–i). k, Metaphase chromosomes from HA–TRF1/Myc–TIN2-13–expressing cell stained with anti-HA antibody (telomeric localization of TRF1 in the presence of TIN2-13). l, Metaphase chromosomes from HA–TRF1/Myc–TIN2-13–expressing cells stained with anti-Myc antibody (telomeric localization of TIN2-13).
   

APPLICATIONS OF TECHNOLOGY:

  • Molecular biology research
  • Medical research

ABSTRACT: Telomeres are believed to be critical regulators of the genome, and telomere stability important for preventing cancer and ageing. Regulation of telomere length is believed to be controlled by multiple telomere-associated proteins. Using a previously cloned human telomere binding protein, Berkeley Lab researchers Sahn-ho Kim and Judith Campisi cloned two novel human telomere-associated proteins, TANK-2 and TIN-2. The full length sequence of one, and a partial sequence of the other is known. TANK-2 and TIN-2 may be important telomere regulators, and therefore of interest in the health care arena for the diagnosis or treatment of cancer or age-related diseases.


STATUS: U.S. Patent #6,409,648. Available for licensing

PUBLICATIONS: 
"TIN2, a new regulator of telomere length in human cells," Sahn-ho Kim, Patrick Kaminker & Judith Campisi, Nature volume 23 no. 4 pp 405 - 412 (1999)

REFERENCE NUMBER: IB-1317

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