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Research Resources

A wide variety of very advanced scientific equipment is being operated in the laboratories of Life Sciences researchers. Due to the complexity of the instrumentation and because most of the groups are actively developing these facilities, most of these resources are available to other researchers in the division through collaborations rather than as service cores. For access to these resources, please contact directly the scientist responsible for the resource. Some highlights:

A more complete list of equipment used in the Life Sciences Division can be found here (only viewable by people at Berkeley Lab). Several equipment needs training prior to use, therefore, please always contact the person responsible if interested in the equipment. If listed as a contact on the list you can edit the list directly. You may also contact the listmaster to edit the list or to receive editing permission.

Biomedical Isotope Facility (BIF)

The Biomedical Isotope Facility (BIF) is dedicated to research and the production of radioactive substances relevant to biomedical imaging. A range of short-lived isotopes is produced using a CTI-Siemens RDS111 cyclotron.  Researchers at Berkeley Lab incorporate these isotopes into radiopharmaceuticals for diagnostic imaging studies with Positron Emission Tomography (PET).  In addition, other research interests include the use of short-lived positron isotopes for non-medically related tracer studies, development of new radiochemical synthetic techniques and training of scientists in radiopharmaceutical synthesis.
Contact: Jim P. O’Neil

Flow Cytometry/Sorting

The Biosciences FACS facility at the Potter Street location has a Becton-Dickinson FACS Vantage SE high speed flow sorter and Becton-Dickinson FACS Calibur flow cytometer. The facility provides training in the use of the instruments and can provide limited with-operator service.
Contact: Michelle Scott
Website: http://www.lbl.gov/lsd/Research/Resources/FACS.html

Mass Spectrometry - Metabolomics "Center for Bioanalytical Innovation"

Research in the Northen Lab is focused on developing and applying mass spectrometry based metabolomic technologies to understand and validate metabolic pathways in microorganism and communities as well as to gain insights into human disease. Capabilities include NIMS tissue imaging, single cell analysis, Nimzyme, LC-MS/MS, GC/MS, METLIN, XCMS, and custom bioinformatics tools.
Contact: Trent Northen
Website: http://masspec.scripps.edu/lbnl%20ms/lblcms_index.php

Mass Spectrometry – Proteomics

The Proteomics Research Laboratory (Wang Lab) is engaged in developing proteomic technologies and methodologies (Anal. Chem. 2007, 79, 3703; J. Proteome. Res. 2007, 6, 3718), and in applying proteomics and metabolomics to study stem cells (JBC, 2004, 279, 43725; Proteomics, 2005, 5, 4414).
Contact: Daojing Wang

Advanced Light Microscopy

A comprehensive light microscopy facility at the Potter Street location provides access to confocal microscopy on two Zeiss LSM 710 microscopes and on a spinning disk-based high-speed microscope for live-cell imaging. For regular fluorescence digital microscopy the facility has an inverted and an upright standard wide-field fluorescence microscope system as well as a multispectral wide-field upright microscope. A number of individual labs in the division have a wide variety of microscopy systems that may be available for access such as two DeltaVision deconvolution microscopes in in the Potter St building, two Zeiss confocal microscopes in building 83, a Zeiss LSM 410 in building 84, and wide-field digital microscopes in a number of locations.
Contacts: Damir Sudar and Michelle Scott
Website: http://www.instrumentschedule.com/fom