A wide variety of very advanced scientific equipment is being operated in the laboratories of Life Sciences Division researchers. Due to the complexity of the equipment and because most of the groups are actively developing them, most of these resources are available to other researchers in the division through collaborations rather than as service cores. For access, please contact directly the person responsible for the equipment. Some highlights:
- Biomedical Isotope Facility (BIF)
- FACS Facility: Flow Cytometry/Sorting
- Mass Spectrometry - Metabolomics
- Mass Spectrometry - Omics
- Advanced Light Microscopy
A more complete list of equipment used in the Life Sciences Division can be found here (only viewable by people at Berkeley Lab). Several equipment needs training prior to use, therefore, please always contact the person responsible if interested in using the equipment. If listed as a contact on the list you can edit the list directly. Alternatively, contact the listmaster to edit the list or to receive editing permission.
The Biomedical Isotope Facility (BIF) is dedicated to research and the production of radioactive substances relevant to biomedical imaging. A range of short-lived isotopes is produced using a CTI-Siemens RDS111 cyclotron. Researchers at Berkeley Lab incorporate these isotopes into radiopharmaceuticals for diagnostic imaging studies with Positron Emission Tomography (PET). In addition, other research interests include the use of short-lived positron isotopes for non-medically related tracer studies, development of new radiochemical synthetic techniques and training of scientists in radiopharmaceutical synthesis.
Contact: Jim P. O’Neil
The Biosciences FACS facility at the Potter Street location has a Becton-Dickinson FACS Vantage SE high speed flow sorter and Becton-Dickinson FACS Calibur flow cytometer. The facility provides training in the use of the instruments and can provide limited with-operator service.
Contact: Michelle Scott
Research in the Northen Lab is focused on developing and applying mass spectrometry based metabolomic technologies to understand metabolic pathways for development of biofuels, predict the responses of microbial communities to climate change and gain insights into low-dose ionization effects especially cancer development. The Northen Lab is particularly interested in alterations between proliferative and growth arrested states.
Capabilities include NIMS and MALDI tissue imaging, high throughput mass spectrometry screening, comprehensive metabolomics(LC-MS/MS, GC/MS) and computational approaches to studying and modeling metabolism.
The Omics Research Laboratory (Wang Lab) is engaged in developing new technologies for proteomics and metabolomics, particularly related to Single Cell Omics; and in applying proteomics and metabolomics to develop bioenergy, and to study cancer biology and stem cell biology.
Contact: Daojing Wang
A comprehensive light microscopy facility at the Potter Street location provides access to confocal microscopy on two Zeiss LSM 710 microscopes and on a spinning disk-based high-speed microscope for live-cell imaging. For regular fluorescence digital microscopy the facility has an inverted and an upright standard wide-field fluorescence microscope system as well as a multispectral wide-field upright microscope. A number of individual labs in the Life Sciences Division have a wide variety of microscopy systems that may be available for access such as two DeltaVision deconvolution microscopes in in the Potter Street building, two Zeiss confocal microscopes in building 83, a Zeiss LSM 410 in building 84, and wide-field digital microscopes in a number of locations.
Contacts: Damir Sudar and Michelle Scott