Northen Lab
Research Interest
Dr. Northen's research aims to construct detailed models of cellular communities metabolism and energetics. This requires mapping the connectivity, dynamics and spatial topography of the system and is accomplished using an integrated program of metabolite imaging and metabolomic analysis. This approach is being applied to understand the dynamics of microbial communities as well as the metabolic drivers of breast cancer and Huntington's disease. Read more about the Molecular Cartography Project at Berkeley Lab here.
Recent Publications
Wilmes, Paul; Bowen, Benjamin P; Thomas Brian C; Mueller Ryan S; Denef Vincent J; VerBerkmoes Nathan C; Hettich Robert L; Northen Trent R; and Banfield Jillian F. Metabolome-proteome differentiation coupled to microbial divergence. mBio (in Press).
Facciotti M.T., Pang W.L., Lo F-Y., Whitehead K., Koide T., Masumura K., Pan M., Kaur A., Larsen D.J., Reiss D.J., Hoang L., Kalisiak E., Northen T., Trauger S.A., Siuzdak G., Baliga N.S. Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive system analysis. BMC Systems Biology 4:64 (2010).
Baran R, Bowen BP, Bouskill NJ, Brodie EL, Yannone SM, Northen TR (2010) Metabolite Identification in Synechococcus sp. PCC 7002 Using Untargeted Stable Isotope Assisted Metabolite Profiling. Analytical Chemistry 82(21): 9034–9042.
Lee, Do Yup, Bowen, Benjamin P, Northen, Trent R. Mass spectrometry based metabolomics, analysis of metabolite-protein interactions, and imaging. Biotechniques, (2010), 49(2): 557-65 (COVER).
Bowen, Benjamin P., Northen, Trent. Dealing with the unknown: Metabolomics and Metabolite Atlases, JASMS (2010). 21(9):1471-1476.
Jansson, Christer, Northen, Trent. Calcifying cyanobacteria-the potential of biomineralization for carbon capture and storage. curr opin biotechnol (2010) 2010 Jun;21(3):365-71.
Reindl, Wolfgang; Northen, Trent. Rapid Screening of Fatty Acids Using Nanostructure-Initiator Mass Spectrometry. Analytical Chemistry (2010), 9, 3751-3755.
Baran, Richard; Reindl, Wolfgang; Northen, Trent. Mass Spectrometry Based Metabolomics and Enzymatic Assays for Functional Genomics. Current Op. in Microbiology (2009), 12, 547-552 COVER.
Woo, Hin-Koon; Go, Eden P; Hoang, Linh; Trauger, Sunia A.; Bowen, Benjamin; Siuzdak, Gary; Northen, Trent R.. Phosphonium Labeling for Increasing Metabolomic Coverage of Neutral Lipids using ESI-MS. Rapid. Comm. Mass Spec. (2009) 23(12), 1849-55.
Northen Trent R, Lee J-C, Hoang L., Raymond J., Hwang D-R, Yannone S.M., Wong C-H, Siuzdak G. A Nanostructure-Initiator Mass Spectrometry Based Enzyme Activity Assay, PNAS, (2008) 105(10), 3678-3683.
Northen T.R. Greving M., Woodbury N.W. Combinatorial Screening of Biomimetic Protein Affinity Materials. Advanced Materials (2008) 20, 1-7.
Woo H-K., Northen T.R., Yanes O., Siuzdak G. Nanostructure-Initiator Mass Spectrometry (NIMS): A protocol for preparing and applying NIMS surfaces for high sensitivity mass analysis. Nature Protocols 3, 1341-1349 (2008).
Northen, Trent R; Wu, Hin-Koon, Northen, Michael T; Nordström, Anders; Uritboonthai, Winnie; Turner, Kimberly L., Sizudak, Gary. High Surface Energy of Porous Silicon Drives Desorption of Intact Molecules. JASMS (2007) 18 (11), 1945-1949.
Northen, Trent R; Yanes, Oscar; Northen, Michael T; Marrinucci, Dena C; Uritboonthai, Winnie; Apon, Junefredo ; Golledge, Stephen L; Nordström, Anders; Sizudak, Gary. Clathrate Nanostructures for Mass Spectrometry. Nature (2007) 449, 1033-1036.
