Kronenberg Lab
Research Interest
The Kronenberg lab conducts research related to the consequences of exposure of ionizing radiation, which was documented as the first environmental mutagen eighty years ago. Our work addresses the regulation of mutagenesis through pathways that link genome surveillance and apoptotic regulation. Related studies address the role of the tissue microenvironment in modulating the effects of radiation exposure. Specialized studies address the dynamics of the physics of charged particle exposures, the impact of the tissue environment, and the maintenance of genomic stability.
Selected Publications
Sudo, H., Garbe, J., Stampfer, M.R., Barcellos-Hoff, M.H., and Kronenberg, A. Karyotypic instability and centrosome aberrations in the progeny of finite lifespan human mammary epithelial cells exposed to sparsely or densely ionizing radiation. Radiation Research 170:23-37, 2008.
Lenarczyk, M. , Ueno, A, Vannais, D.B., Kraemer, S., Kronenberg, A., Roberts, J.R., Tatsumi, K., Hei, T.,K. and Waldren, C.A. The "pro-drug" RibCys decreases the mutagenecity of high LET radiation in cultured mammalian cells. Radiation Research 160:579-583, 2003.
Wiese, C., Pierce, A.J., Gauny, S.S., Jasin, M. and Kronenberg, A. Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-XL. Cancer Research, 62:1279-1283, 2002.
Wiese, C., Collins, D.W., Albala, J.S., Thompson, L.H., Kronenberg, A. and Schild, D. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. Nucleic Acids Research, 30: 1009-1105, 2002.
Wiese, C., Gauny, S., Liu, W., Cherbonnel-Lasserre, C. and Kronenberg, A. Different mechanisms of radiation-induced loss of heterozygosity in two human lymphoid cell lines from a single donor. Cancer Research 61:1129-1137, 2001.
Kraemer, S., Vannais, D.B., Kronenberg, A., Ueno, A., and Waldren C.A. Gamma-ray mutagenesis studies in a new human-hamster hybrid, ALCD59+/-, which has two human chromosomes 11 but is hemizygous for the CD59 gene. Radiation Research 156:10-19, 2001.
Wiese, C., Gauny, S., Liu, W., Cherbonnel-Lasserre, C. and Kronenberg, A. Different mechanisms of radiation-induced loss of heterozygosity in two human lymphoid cell lines from a single donor. Cancer Research 61:1129-1137, 2001.
Kraemer, S.M., Kronenberg, A., Ueno, A. and Waldren, C.A. Measuring the spectrum of mutations induced by nitrogen ions and protons in the human-hamster hybrid cell line ALC. Radiation Research, 153:743-751, 2000.
Cherbonnel-Lasserre, C., Gauny, S., and Kronenberg, A. Suppression of apoptosis by Bcl-2 or Bcl-XL promotes susceptibility to mutagenesis. Oncogene, 13:1489-1497, 1996.
Cherbonnel-Lasserre, C., Gauny, S., and Kronenberg, A. Suppression of apoptosis by Bcl-2 or Bcl-XL promotes susceptibility to mutagenesis. Oncogene, 13:1489-1497, 1996.
