The Department of Molecular and Nuclear Medicine is revitalizing traditional nuclear medicine through the use of new chemical probes and new instrumentation for applications to aging, atherosclerosis, and cancer. At the Center for Functional Imaging (CFI) advanced positron emission tomography and nuclear magnetic resonance techniques are being developed and used to study cardiac function and brain disorders such as Alzheimer's and Parkinson's disease. A new minicyclotron, the Biomedical Isotope Facility, has been commissioned for the production of short-lived radioisotopes. Sub-2mm PET is under development, designed to achieve the best spatial resolution and quantitative accuracy for studies of human brain function. CFI is affiliated with the Magnetic Resonance Science Center at UC San Francisco and collaborates with researchers from UCSF and UC Davis. The Lipoprotein and Atherosclerosis Group investigates the involvement of specific lipoproteins in the development of atherosclerosis and coronary heart disease; tools include isotopic tracer studies, human genetic linkage studies, transgenic animal models, and clinical studies.