Within the Department of Subcellular Structure, innovative developments in electron microscopy, UV confocal microscopy, soft x-ray microscopy, and related techniques are used to study the molecular structure and subcellular organization of proteins related to the cytoskeleton and various cell membranes.

Structural analyses by electron crystallography and x-ray crystallography are targeting the transport of solutes and ions across the cell membrane. A new program in computational biology is being developed to complement these ongoing molecular studies. Hematopoiesis research within this department concentrates on characterizing the biology of long-term repopulation of stem cells. Therapies are then sought to mitigate the effects of such disorders as thalessemia, malaria, and sickle-cell anemia.