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Environment, Health, & Safety Division

2.0    Starting and Conducting Work Safely

This section and Table 1 provide a simplified list to assist supervisors, work leads, and principal investigators in getting work with biological materials planned, assessed, authorized, and conducted. Specific sections of this manual and PUB-3000, Chapter 26 (Biosafety) should be consulted for additional information and requirements:

Table 1
Guidance for Starting and Conducting Work

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Guidance

LBNL Policy Section

Work Operation Planning, Risk Assessment, Authorization, and Control
Complete and maintain a Biosafety Work Authorization (i.e., Biological Use Authorization (BUA), Biological Use Registration (BUR), Biological Use Notification (BUN), or Exposure Control Plan (ECP)) and any other required authorization. The Biosafety Work Authorization documents the work, risks, and controls. Implement the controls listed in the authorization.

Biosafety Manual, Section 5.1
PUB-3000, Section 26.8.2
    • Submit the application form to the Environment, Health, and Safety (EH&S) Biosafety Office (BWKing@lbl.gov and VMXian@lbl.gov) for review by the Institutional Biosafety Committee (IBC) and/or Biosafety Officer.
PUB-3000,  Section 26.8.2
    • Resolve any review comments.

 

    • Work with the Biosafety Office to get the completed Biosafety Work Authorization signed and authorized. The Biosafety Office will load the authorization into the Biosafety Authorization System (BAS).
PUB-3000, Table 26-6
    • Ensure workers are familiar with the authorization document, understand the required controls, and are trained.
Biosafety Manual, Section 5.2
    • Ensure the containment controls noted in the authorization document are implemented. Also implement applicable controls noted in PUB-3000, Chapter 26 (Biosafety) and the Biosafety Manual. Standard Laboratory Biosafety Level (BL) 1 and BL2 criteria are summarized in Appendix C.
Biosafety Manual, Sections 4.0 and 5.0
    • Update personnel, biosafety training, and work locations as needed in the BAS.

 

  • Update and submit for review the authorization document to the Biosafety Office prior to the target renewal date. Ensure authorization document is re-authorized as needed.
PUB-3000, Table 26-6
  • Complete and submit an Exposure Control Plan for nonresearch work that involves exposure to bloodborne pathogen materials.
PUB-3000, Section 26.8.3
  • Complete and get approval on any required protocols for research involving vertebrate animals or human subjects (including human-derived data or human-derived tissues) via the Animal Welfare and Research Committee (AWRC) or Human Subjects Committee (HSC), respectively.
PUB-3000,
Chapter 22
   

Worker Authorization and Control
Identify the work, hazards, and controls for each worker or subcontractor and ensure the controls are implemented. Ensure each worker completes:

 

  • A Job Hazards Analysis (JHA) or Subcontractor Job Hazards Analysis and Work Authorization (SJHAWA).
Biosafety Manual, Section 5.2.1
  • Required controls on their JHA or SJHAWA, including required training courses.
Biosafety Manual, Section 5.2.2
  • Applicable job and operation-specific instruction related to biosafety.
Biosafety Manual, Section 5.2.3
  • Any required medical surveillance noted on their JHA, SJHAWA, or work authorization document.
Biosafety Manual, Section 5.3
   

Assessment and Improvement

  • Assess and continuously improve the biosafety of the work.
PUB-3000, Section 26.9
  • Conduct periodic biosafety assessments of the operation as specified in the Division Self-Assessment Program, including assessment of the safety of tasks being performed, safety of the work area and equipment, training, and compliance with the Biosafety Work Authorization and standards.
PUB-3000, Section 26.9
  • Participate in periodic Biosafety or other Environment, Safety, and Health (ES&H) Technical Assurance Program (TAP) assessments of the operation, when scheduled.
PUB-3000, Section 26.9
  • Continuously improve the biosafety of the work, including tracking and correcting deficiencies when required in the Corrective Action Tracking System (CATS).
PUB-3000, Section 26.9
   

Whom to Call
Refer to the Whom to Call list in Section 1.6.

Biosafety Manual, Section 1.6

Work with biological materials, like all work at LBNL, must be conducted using the guiding principles and five core functions of Integrated Safety Management (ISM) (e.g., define scope of work, analyze hazards, develop and implement controls, perform work within controls, feedback and continuous improvement) as discussed in PUB-3000, Section 1.4. These core functions are integrated into the work authorization and control functions summarized above in Table 1.