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| The Berkeley
Lab ex situ NMR and MRI technique can be used for oil
well logging (left), stand-off detection (top
right), and cargo inspection (bottom right). |
APPLICATIONS:
- Industrial sensing
- Oil well logging
- Medical imaging for large subjects
- Spectroscopy
- Imaging subjects or objects with ferromagnetic components
- Cargo inspection
- Stand-off detection
ADVANTAGES:
- Samples can be outside of magnet
- Generates high resolution spectra
- Quick and transportable
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NMR spectrum of trans-2-pentenal
under ordinary high resolution conditions. Peaks corresponding
to the five non-equivalent hydrogen nuclei are observed.
Spectrum with sample
placed in a non-uniform field outside of the rf coil;
all chemical information is lost.
A specially designed rf pulse train (inset rectangles)
nuclei in a non-uniform magnetic field; a high resolution
spectrum is recovered from the emitted signal. |
ABSTRACT:
Alexander Pines and colleagues have opened the way to high
resolution ex situ nuclear magnetic resonance (NMR)
and magnetic resonance imaging (MRI). NMR/MRI experiments
are typically performed with samples immersed in a magnet
shimmed to high homogeneity. However, in many circumstances
it is impractical or undesirable to transport or insert samples
into the bore of a high field magnet.
The Berkeley Lab researchers have developed an NMR/MRI technique
in which a mobile magnet can be scanned over a stationary
sample. The resulting high resolution spectra have full chemical
shift information despite the inhomogeneous static and radio
frequency fields normally associated with ex situ NMR/MRI.
Preliminary experiments using Berkeley Lab’s ex situ
NMR method show that line broadening due to static field gradients
of up to 0.5 mT/cm can be effectively overcome. Berkeley Lab’s
technique has been applied to multidimensional spectroscopy
and can be extended to spin decoupling and multiple-pulse
sequences, and Magic-Angle Spinning (MAS) for static samples
located outside the magnet.
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STATUS:
U.S. Patent
#6,674,282. Available for licensing
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REFERENCE
NUMBER: IB-1717
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PUBLICATION:
Meriles, C.,
Sakalleriou, D., Heise, H., Moule, A., Pines, A., “Approach
to High Resolution Ex Situ NMR Spectroscopy,”
Science 2001, 293, 82-85.
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SEE
THESE OTHER BERKELEY TECHNOLOGIES IN THIS FIELD:
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