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Marker for Human Breast Cancer

IB-1242

APPLICATIONS OF TECHNOLOGY:

  • Human healthcare

ADVANTAGES:

  • Detects human breast cancer in early stage

ABSTRACT:

Mina Bissell

Mina Bissell and colleagues have identified a molecular marker that could detect the early stages of human breast cancer. A comparison of gene expression among cells of a human breast cancer progression series, nonmalignant (S1), premalignant (S2) and malignant (T4-2) human breast cells, shows that the expression of a new gene, named "AZ-1," abruptly declines as cells become tumorigenic. Transcripts of AZ-1, obtained using differential display-PCR, were also not detected in ten other malignant human breast epithelial cell lines, whereas they were present in normal human myoepithelial and luminal epithelial cells. Chromosomal localization of the AZ-1 gene has been mapped by fluorescence in situ hybridization (FISH). AZ-1 was low or absent in 4 primary breast tumors and expressed in normal breast tissue. Based on the inverse relationship of its expression level and tumor phenotype in all of the tumor cell lines and tissues analyzed, AZ-1 is a potential candidate as a tumor marker for human breast cancer.

STATUS:

  • U.S. Patent #6,753,154. Application Available for Licensing.

REFERENCE NUMBER: IB-1242

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Last updated: 09/17/2009