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AVAILABLE
TECHNOLOGIES |
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Safe
and Selective Enhancement of NMR and MRI Using Hyperpolarized Noble
Gases
IB-1168
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APPLICATIONS:
- In vivo and in vitro imaging of biological
systems
- Distinguishing between chemical species in living
organisms (e.g. blood, proteins, lipids)
- Magnetic resonance imaging (MRI)/ magnetic resonance
spectroscopy (MRS) studies on soft-tissue anatomy,
physiology, and pathology
ADVANTAGES:
- Selectively enhances NMR/MRI spin signals in solution
without irradiating organisms at microwave frequencies
- Provides chemical contrasts without injecting organisms
with harmful radioactive isotopes for x-ray imaging
- Allows for high speed protocols
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ABSTRACT:
Alexander
Pines and colleagues at Berkeley Lab and UC Berkeley have enhanced
NMR and MRI using hyperpolarized noble gases. These hyperpolarized
gases are useful as tracers as well as agents which affect the
properties of other nuclei in the sample.
The Berkeley Lab researchers have used hyperpolarized gas solutions
in vitro and in vivo to study the dynamics or structure
of biological systems. For example, researchers were able to
rapidly distinguish between intracellular and extracellular
populations of 129xenon
in a red blood cell sample due to the signal enhancement obtained
through the use of laser polarized xenon.
Researchers also injected a hyperpolarized xenon/ saline solution
into a rat’s thigh muscle and obtained excellent in
vivo MR images. Other research has demonstrated the feasibility
of using intravenously delivered lipid solutions of hyperpolarized
xenon to obtain in vivo xenon NMR spectra.. |
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STATUS:
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REFERENCE
NUMBER: IB-1168
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PUBLICATION:
Navon, G., Song, Y.Q., Room, T., Appelt, S., Taylor, R.E.,
and Pines, A., “Enhancement of Solution NMR and MRI with
Laser-Polarized Xenon,” Science 1996, 271, 1848.
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SEE
THESE OTHER BERKELEY LAB TECHNOLOGIES IN THIS FIELD:
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CONTACT:
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Technology
Transfer Department
E.O. Lawrence Berkeley National Laboratory
MS 90-1070
Berkeley, CA 94720
(510) 486-6467 FAX: (510) 486-6457
TTD@lbl.gov |
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